Enterohepatic, Gluco-metabolic, and Gut Microbial Characterization of Individuals With Bile Acid Malabsorption

Bile Acid Malabsorption/Diarrhoea

Bile acid malabsorption leads to chronic watery, non-bloody diarrhoea. Many patients present with symptoms suggestive of IBS. Idiopathic BAM (no obvious cause) occurs in both men and women, mostly between the ages of 30 and 70. There is often a long history of diarrhoea at the time of diagnosis, sometimes lasting longer than 10 years. The diarrhoea is continuous or intermittent; nocturnal diarr...

Enterohepatic bile acid transporters and transcriptional control of their expression

Bile Acid Malabsorption: A Concise Review

Submit Manuscript | http://medcraveonline.com Abbreviations: BAM: Bile Acid Malabsorption; CA: Cholic Acid; CDCA: Chenodeoxycholic Acid; DCA: Deoxycholic Acid; ASBT: Apical Sodium-dependent Bile Acid Transporter; IBS-D: Diarrhea-Predominant Irritable Bowel Syndrome; SeHCAT: Selenium HomotauroCholic Acid Test, FGF: Fibroblast growth factor; GPBAR1: G Protein-coupled Bile Acid Receptor 1; CYP7A1:...

Intestinal bile acid malabsorption in cystic fibrosis.

This study aimed at examining the mechanisms participating in excessive faecal bile acid loss in cystic fibrosis. The study was designed to define the relation between faecal fat and faecal bile acid loss in patients with and without cystic fibrosis related liver disease; to assess terminal ileal bile acid absorption by a seven day whole body retention of selenium labelled homotaurocholic acid ...

Microbial bile acid metabolic clusters: the bouncers at the bar.

Colonization resistance refers to the ability of the colonic microbiota to prevent invasion by pathogens including Clostridium difficile. In a recent article, Buffie et al. (2014) have demonstrated that a single metabolic cluster present in the normal, colonic microflora is responsible for preventing C. difficile invasion of healthy hosts.